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Most of the antibiotics now in use have been discovered more or
less by chance, and their mechanisms of action have only been
elucidated after their discovery. To meet the medical need for
next-generation antibiotics, a more rational approach to antibiotic
development is clearly needed.
Opening with a general introduction about antimicrobial drugs,
their targets and the problem of antibiotic resistance, this
reference systematically covers currently known antibiotic classes,
their molecular mechanisms and the targets on which they act. Novel
targets such as cell signaling networks, riboswitches and bacterial
chaperones are covered here, alongside the latest information on
the molecular mechanisms of current blockbuster antibiotics.
With its broad overview of current and future antibacterial drug
development, this unique reference is essential reading for anyone
involved in the development and therapeutic application of novel
antibiotics.
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